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Photonic Cancer Nanomedicine at Near Infrared-II Biowindow Enabled by Biocompatible Titanium Nitride Nanoplatforms

Abstract

Light-activated photoacoustic imaging (PAI) and photothermal therapy (PTT) in the second near-infrared biowindow (NIR-II, 1000-1350 nm) holds great promise for efficient tumor detection and diagnostic imaging-guided photonic nanomedicine. In this work, we report on the construction of titanium nitride (TiN) nanoparticles with high photothermal-conversion efficiency and desirable biocompatibility as an alternative theranostic agent for NIR-II laser-excited photoacoustic (PA) imaging-guided photothermal tumor hyperthermia. Working at the NIR-II biowindow provides larger maximum permissible exposure (MPE) and desirable penetration depth of light, which then achieves full extent detection of tumor by PA imaging and complete tumor ablation by photothermal ablation, especially in deeper regions. After further surface polyvinyl-pyrrolidone (PVP) modification, these TiN-PVP photothermal nanoagents exhibit high photothermal conversion efficiency of 22.8% at NIR-II biowindow, and further verify their high penetration depth at NIR-II biowindow and corresponding therapeutic effect on viability of tumor cells in vitro. Furthermore, these TiN-PVP nanoparticles were developed as the contrast agents for NIR-II-activated PA imaging both in vitro and in vivo for the first time and realized efficient photothermal ablation of tumor in vivo under both NIR-I and NIR-II biowindows. This work not only provides the paradigm (TiN-PVP) of photothermal nanoagents working at NIR-II biowindow both in vitro and in vivo, but also proves the feasible cancer-theranostic application in PAI and PTT under NIR-II laser excitation.

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Publication details

The article was received on 12 Sep 2018, accepted on 10 Oct 2018 and first published on 10 Oct 2018


Article type: Communication
DOI: 10.1039/C8NH00299A
Citation: Nanoscale Horiz., 2018, Accepted Manuscript
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    Photonic Cancer Nanomedicine at Near Infrared-II Biowindow Enabled by Biocompatible Titanium Nitride Nanoplatforms

    C. Wang, D. Chen, Z. Hu, H. Li, L. Yu, H. Lin, J. Bai and Y. Chen, Nanoscale Horiz., 2018, Accepted Manuscript , DOI: 10.1039/C8NH00299A

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