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Issue 12, 2018
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The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(II) from albumin. Implications for copper uptake by Ctr1

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Abstract

Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 CuII is bound to the model peptide hCtr11–14via an ATCUN motif and such complexes are strong enough to collect CuII from albumin, supporting the potential physiological role of CuII binding to hCtr1.

Graphical abstract: The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1

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Publication details

The article was received on 26 Sep 2018, accepted on 21 Nov 2018 and first published on 23 Nov 2018


Article type: Communication
DOI: 10.1039/C8MT00274F
Citation: Metallomics, 2018,10, 1723-1727
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    The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(II) from albumin. Implications for copper uptake by Ctr1

    E. Stefaniak, D. Płonka, S. C. Drew, K. Bossak-Ahmad, K. L. Haas, M. J. Pushie, P. Faller, N. E. Wezynfeld and W. Bal, Metallomics, 2018, 10, 1723
    DOI: 10.1039/C8MT00274F

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