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Shared gene-network signatures between human heavy metal proteome, neurological disorders and cancer types.

Abstract

In this work, for the first time, the human heavy metal proteome was predicted. According to the results, aluminum, cadmium, mercury and lead metalloproteome might constitute up to 8,9 %, 18,4 %, 15 % and 4 % of the entire human proteome respectively. The abundance of the predicted heavy metal-binding proteins in various organ-specific proteomes was retrieved by Human Protein Atlas database showing higher expression profiles for Cd-and Hg-binding proteins in all studied organs (especially in prostate, heart and pancreas) compared with the other heavy metal. Possible perturbations in cellular trafficking and homeostasis of essential metals by heavy metal proteomes were highlighted. Furthermore, this study showed that molecular linkages between heavy metal proteomes and major neurological disorders or various types of cancer were more significant for Cd followed by Hg, Al and Pb. Interestingly, integrated gene network analysis revealed that Cd and Hg proteomes share so far unknown, gene circuits with these two types of disorders.

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Publication details

The article was received on 21 Sep 2018, accepted on 03 Oct 2018 and first published on 03 Oct 2018


Article type: Paper
DOI: 10.1039/C8MT00271A
Citation: Metallomics, 2018, Accepted Manuscript
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    Shared gene-network signatures between human heavy metal proteome, neurological disorders and cancer types.

    C. T. Chasapis, Metallomics, 2018, Accepted Manuscript , DOI: 10.1039/C8MT00271A

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