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Issue 11, 2018
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Cyclometallated Au(III) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

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Abstract

A series of cationic mixed cyclometallated (C^N)Au(III) dithiocarbamate complexes has been synthesized in good yields [HC^N = 2-(p-t-butylphenyl)pyridine]. The crystal structure of [(C^N)AuS2CNEt2]PF6 (3) has been determined. The cytotoxic properties of the new complexes have been evaluated in vitro against a panel of human cancer cell lines and healthy cells and compared with a neutral mixed (C^C)Au(III) dithiocarbamate complex (C^C = 4,4′-di-t-butylbiphenyl-2,2′-diyl). The complexes appeared to be susceptible to reduction by glutathione but were stable in the presence of N-acetyl cysteine. The potential mechanism of action of this class of compounds has been investigated by measuring the intracellular uptake of some selected complexes, by determining their interactions with higher order DNA structures, and by assessing the ability to inhibit thioredoxin reductase. The complexes proved unable to induce the formation of reactive oxygen species. The investigations add to the picture of the possible mode of action of this class of complexes.

Graphical abstract: Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

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Publication details

The article was received on 03 Aug 2018, accepted on 18 Sep 2018 and first published on 18 Sep 2018


Article type: Paper
DOI: 10.1039/C8MT00225H
Citation: Metallomics, 2018,10, 1655-1666
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    Cyclometallated Au(III) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

    M. R. M. Williams, B. Bertrand, D. L. Hughes, Z. A. E. Waller, C. Schmidt, I. Ott, M. O’Connell, M. Searcey and M. Bochmann, Metallomics, 2018, 10, 1655
    DOI: 10.1039/C8MT00225H

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