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Issue 6, 2018
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A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(ii)

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Abstract

Mitochondria are iron-rich organelles that are involved in the process of energy production through the electron-transporting system and heme synthesis. We developed a new mitochondria-targeted fluorescent probe, MtFluNox/Ac-MtFluNox, for Fe(II) based on N-oxide chemistry, which we recently established as a Fe(II)-selective fluorogenic switch. The deacetylated form MtFluNox showed a turn-on response towards Fe(II) with high metal selectivity in cuvette experiments, and an imaging study using its cell-compatible analogue Ac-MtFluNox demonstrated mitochondria-specific fluorescence enhancement in response to Fe(II) in living cells. Furthermore, the probe was able to detect endogenously accumulated Fe(II) induced as a result of the inhibition of heme synthesis.

Graphical abstract: A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(ii)

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Supplementary files

Article information


Submitted
06 Mar 2018
Accepted
21 May 2018
First published
21 May 2018

Metallomics, 2018,10, 794-801
Article type
Paper

A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(II)

T. Hirayama, S. Kadota, M. Niwa and H. Nagasawa, Metallomics, 2018, 10, 794
DOI: 10.1039/C8MT00049B

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