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Issue 4, 2018
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A ratiometric iron probe enables investigation of iron distribution within tumour spheroids

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Abstract

Iron dysregulation is implicated in numerous diseases, and iron homeostasis is profoundly influenced by the labile iron pool (LIP). Tools to easily observe changes in the LIP are limited, with calcein AM-based assays most widely used. We describe here FlCFe1, a ratiometric analogue of calcein AM, which also provides the capacity for imaging iron in 3D cell models.

Graphical abstract: A ratiometric iron probe enables investigation of iron distribution within tumour spheroids

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Supplementary files

Article information


Submitted
25 Oct 2017
Accepted
27 Mar 2018
First published
16 Apr 2018

This article is Open Access

Metallomics, 2018,10, 553-556
Article type
Communication

A ratiometric iron probe enables investigation of iron distribution within tumour spheroids

I. J. Carney, J. L. Kolanowski, Z. Lim, B. Chekroun, A. G. Torrisi, T. W. Hambley and E. J. New, Metallomics, 2018, 10, 553
DOI: 10.1039/C7MT00297A

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