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Identifying glioblastoma margin using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy

Abstract

Current therapeutics for glioblastoma multiforme (GBM) treatment are unsatisfying due to their limited ability to control the progression from tumour margins. In this work, organic nanoparticles (NPs) are synthesized by co-encapsulating a fluorogen with aggregation-induced emission to generate bright red emission for imaging and a semiconducting polymer to offer NIR absorption for photothermal therapy. The NPs are further modified with different ratios of two targeting ligands, folate and cRGD peptide. The best ratio that performing specific and efficient GBM targeting is screened out through in vitro and ex vivo fluorescence imaging analysis. The NPs with an FA to cRGD ratio of 25:75 exhibit superior ability to target GBM cell in vitro and also show efficient accumulation at GBM margin and interior after in vivo administration. The progression of GBM can be greatly suppressed through photothermal therapy, which provides a simple but promising strategy for GBM treatment.

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Publication details

The article was received on 08 Aug 2018, accepted on 12 Oct 2018 and first published on 13 Oct 2018


Article type: Communication
DOI: 10.1039/C8MH00946E
Citation: Mater. Horiz., 2018, Accepted Manuscript
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    Identifying glioblastoma margin using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy

    X. Cai, A. Bandla, C. K. Chuan, G. Magarajah, L. Liao, D. B. L. Teh, B. K. Kennedy, N. Thakor and B. Liu, Mater. Horiz., 2018, Accepted Manuscript , DOI: 10.1039/C8MH00946E

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