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Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

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Abstract

Developing a simple and degradable synergistic therapy nanosystem based on glucose oxidase (GOx) remains a challenge. Inspired by the chain reactions among silver nanoparticles, GOx and intratumoral glucose, a degradable GOx-conjugated silver nanocube (AgNC–GOx) for synergistic cancer starving-like/metal ion therapy is presented. The combination of glucose depletion, toxic H2O2 and Ag ions effectively inhibits tumor growth with minimal adverse effects.

Graphical abstract: Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

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Publication details

The article was received on 05 Aug 2018, accepted on 11 Oct 2018 and first published on 23 Oct 2018


Article type: Communication
DOI: 10.1039/C8MH00908B
Citation: Mater. Horiz., 2018, Advance Article
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    Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

    Y. Zhang, Y. Yang, S. Jiang, F. Li, J. Lin, T. Wang and P. Huang, Mater. Horiz., 2018, Advance Article , DOI: 10.1039/C8MH00908B

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