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Engineering hyperthermostable rcSso7d as reporter molecule for in vitro diagnostic tests

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Abstract

The hyperthermostable binding scaffold, rcSso7d, has recently been studied for use in in vitro diagnostic tests but has not yet been demonstrated as a soluble reporter protein. Here, we investigated several rcSso7d protein constructs and biotin conjugation methods to link a detectable signal to the presence of a target biomarker.

Graphical abstract: Engineering hyperthermostable rcSso7d as reporter molecule for in vitro diagnostic tests

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Publication details

The article was received on 31 Jul 2018, accepted on 15 Oct 2018 and first published on 15 Oct 2018


Article type: Communication
DOI: 10.1039/C8ME00049B
Citation: Mol. Syst. Des. Eng., 2018, Advance Article
  • Open access: Creative Commons BY-NC license
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    Engineering hyperthermostable rcSso7d as reporter molecule for in vitro diagnostic tests

    K. Sung, E. A. Miller and H. D. Sikes, Mol. Syst. Des. Eng., 2018, Advance Article , DOI: 10.1039/C8ME00049B

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