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Issue 4, 2018
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Nitro sulfonyl fluorides are a new pharmacophore for the development of antibiotics

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Abstract

The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa.

Graphical abstract: Nitro sulfonyl fluorides are a new pharmacophore for the development of antibiotics

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Publication details

The article was received on 05 Mar 2018, accepted on 07 Jun 2018 and first published on 07 Jun 2018


Article type: Communication
DOI: 10.1039/C8ME00011E
Mol. Syst. Des. Eng., 2018,3, 599-603

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    Nitro sulfonyl fluorides are a new pharmacophore for the development of antibiotics

    C. Sadlowski, B. Park, C. Araujo Borges, S. Das, D. Lucas Kerr, M. He, H. Han, L. Riley and N. Murthy, Mol. Syst. Des. Eng., 2018, 3, 599
    DOI: 10.1039/C8ME00011E

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