Jump to main content
Jump to site search

Issue 11, 2018
Previous Article Next Article

Synthesis and biological evaluation of 3-(1,3,4-oxadiazol-2-yl)-1,8-naphthyridin-4(1H)-ones as cisplatin sensitizers

Author affiliations

Abstract

A series of novel 3-(1,3,4-oxadiazol-2-yl)-1,8-naphthyridin-4(1H)-one derivatives were synthesized and their anti-cancer as well as cisplatin sensitization activities were evaluated. Among them, compounds 6e and 6h exhibited significant cisplatin sensitization activity against HCT116. Hoechst staining and annexin V-FITC/PI dual-labeling studies demonstrated that the combination of 6e/6h and cisplatin can induce tumour cell apoptosis. Western blot showed that the expression of ATR downstream protein, CHK1, decreased in 6e + cisplatin and 6h + cisplatin groups compared with that in the test compound and cisplatin group. Furthermore, docking of 6e/6h into the ATR structure active site revealed that the N1 and N8 atoms in the naphthyridine ring and the hybrid atom in the oxadiazole ring are involved in hydrogen bonding with Val170, Glu168 and Tyr155. Additionally, the naphthyridine ring is also involved in π–π stacking with Trp169. Accordingly, compounds 6e and 6h can be expected to be potential cisplatin sensitizers that can participate in HCT116 cancer therapy.

Graphical abstract: Synthesis and biological evaluation of 3-(1,3,4-oxadiazol-2-yl)-1,8-naphthyridin-4(1H)-ones as cisplatin sensitizers

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Sep 2018, accepted on 22 Sep 2018 and first published on 25 Sep 2018


Article type: Research Article
DOI: 10.1039/C8MD00464A
Citation: Med. Chem. Commun., 2018,9, 1949-1960
  •   Request permissions

    Synthesis and biological evaluation of 3-(1,3,4-oxadiazol-2-yl)-1,8-naphthyridin-4(1H)-ones as cisplatin sensitizers

    X. Hou, H. Luo, M. Zhang, G. Yan, C. Pu, S. Lan and R. Li, Med. Chem. Commun., 2018, 9, 1949
    DOI: 10.1039/C8MD00464A

Search articles by author

Spotlight

Advertisements