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Issue 12, 2018
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Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite

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Abstract

S-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O2˙ promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO). Since the production of O2˙ can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in medicine.

Graphical abstract: Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite

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Publication details

The article was received on 24 Aug 2018, accepted on 21 Oct 2018 and first published on 24 Oct 2018


Article type: Research Article
DOI: 10.1039/C8MD00414E
Citation: Med. Chem. Commun., 2018,9, 1994-1999
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    Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite

    R. Alhasan, A. Kharma, M. J. Nasim, A. Y. Abdin, J. Bonetti, P. Giummelly, C. E. C. C. Ejike, P. Leroy, C. Gaucher and C. Jacob, Med. Chem. Commun., 2018, 9, 1994
    DOI: 10.1039/C8MD00414E

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