Jump to main content
Jump to site search

Issue 12, 2018
Previous Article Next Article

Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies

Author affiliations

Abstract

CA IX has attracted much attention as a promising target for the development of new anticancer agents. In this study, a series of sulfonamide derivatives were designed and synthesized as potential CA IX inhibitors from a lead compound (benzoyl thioureido benzene sulfonamide) discovered by virtual screening. The bioassay demonstrated that some of the synthesized compounds exhibited potent inhibitory activity against CA IX in the subnanomolar range and high selectivity over isozymes CA I and CA II. Among them, compound 6a displayed inhibitory activity against CA IX with an IC50 value of 0.48 nM and about 1500-fold selectivity over CA II. The structure–activity relationship and CA IX selectivity of the new sulfonamide derivatives were also analyzed by molecular docking.

Graphical abstract: Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies

Back to tab navigation

Article information


Submitted
11 Aug 2018
Accepted
05 Nov 2018
First published
09 Nov 2018

Med. Chem. Commun., 2018,9, 2100-2105
Article type
Research Article

Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies

L. Liu, W. Wang, J. Huang, Z. Zhao, H. Li and Y. Xu, Med. Chem. Commun., 2018, 9, 2100
DOI: 10.1039/C8MD00392K

Search articles by author

Spotlight

Advertisements