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Issue 12, 2018
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Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

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Abstract

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei. Our study identified compounds 35, 39, 46, 53 and 56 whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.

Graphical abstract: Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

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Supplementary files

Article information


Submitted
27 Jun 2018
Accepted
30 Sep 2018
First published
26 Oct 2018

This article is Open Access

Med. Chem. Commun., 2018,9, 2037-2044
Article type
Research Article

Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

C. G. L. Veale and H. C. Hoppe, Med. Chem. Commun., 2018, 9, 2037
DOI: 10.1039/C8MD00319J

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