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2-Aminobenzimidazoles as Antibiofilm Agents Against Salmonella enterica Serovar Typhimurium

Abstract

Serovars within the species Salmonella enterica are some of the most common food and water-borne pathogens worldwide. Some S. enterica species have shown a remarkable ability to persist both inside and outside the human body. Salmonella enterica serovar Typhi can cause chronic, asymptomatic infection of the human gallbladder. This organism’s ability to survive inside the gallbladder centers around its ability to form biofilms on gallstone surfaces. Currently, chronic carriage of S. Typhi is treated by invasive methods, which are not well suited to areas where Salmonella carriage is prevalent. Herein, we report 2-aminobenzimidazoles that inhibit S. enterica serovar Typhimurium (a surrogate for S. Typhi) biofilm formation in low micromolar concentrations. Modifications to the head, tail, and linker regions of the original hit compound elucidated new, more effective analogues that inhibit S. Typhimurium biofilm formation while being non-toxic to planktonic bacterial growth.

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Publication details

The article was received on 12 Jun 2018, accepted on 31 Jul 2018 and first published on 02 Aug 2018


Article type: Research Article
DOI: 10.1039/C8MD00298C
Citation: Med. Chem. Commun., 2018, Accepted Manuscript
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    2-Aminobenzimidazoles as Antibiofilm Agents Against Salmonella enterica Serovar Typhimurium

    W. Huggins, T. V. Nguyen, N. Hahn, J. Baker, L. Kuo, D. Kaur, R. Worthington, J. Gunn and C. Melander, Med. Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8MD00298C

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