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Synthesis of novel Perillyl-Dihydropyrimidinone hybrids designed for antiproliferative activity

Abstract

A series of fifteen novel dihydropyrimidinone hybrid compounds were synthesized via multicomponent reaction combined with Huisgen reaction in good yields. The antiproliferative activity was investigated against nine tumor cell lines and four hybrid compounds (TGI < 10M) showed promising antiproliferative activity against OVCAR-3 (ovarian), UACC-62 (melaoma) and U251 (glioma) tumor cell lines. Several hybrid compounds assayed have high TGI values ( TGI 147.92-507.82) for the human keratinocytes cell line (HaCat),which reveals selectivity to cancer cells.

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Publication details

The article was received on 26 May 2018, accepted on 27 Jul 2018 and first published on 31 Jul 2018


Article type: Research Article
DOI: 10.1039/C8MD00270C
Citation: Med. Chem. Commun., 2018, Accepted Manuscript
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    Synthesis of novel Perillyl-Dihydropyrimidinone hybrids designed for antiproliferative activity

    V. Vendrusculo, V. P. de Souza, L. A. Mazzini Fontoura, M. G. Montes D'Oca, T. P. Banzato, P. A. Monteiro, R. Pilli, J. Carvalho and D. Russowsky, Med. Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8MD00270C

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