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Issue 9, 2018
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Synthesis of novel perillyl–dihydropyrimidinone hybrids designed for antiproliferative activity

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Abstract

A series of fifteen novel dihydropyrimidinone hybrid compounds were synthesized in good yields via a multicomponent reaction combined with the Huisgen reaction. The antiproliferative activity was investigated against nine tumor cell lines, and four hybrid compounds (TGI < 10 μM) showed promising antiproliferative activity against the tumor cell lines OVCAR-3 (ovarian), UACC-62 (melanoma) and U251 (glioma). Several hybrid compounds assayed have high TGI values (TGI 147.92–507.82) for the human keratinocyte cell line (HaCat), which reveals selectivity to cancer cells.

Graphical abstract: Synthesis of novel perillyl–dihydropyrimidinone hybrids designed for antiproliferative activity

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Publication details

The article was received on 26 May 2018, accepted on 27 Jul 2018 and first published on 31 Jul 2018


Article type: Research Article
DOI: 10.1039/C8MD00270C
Citation: Med. Chem. Commun., 2018,9, 1553-1564
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    Synthesis of novel perillyl–dihydropyrimidinone hybrids designed for antiproliferative activity

    V. Vendrusculo, V. P. de Souza, L. A. M. Fontoura, M. G. M. D'Oca, T. P. Banzato, P. A. Monteiro, R. A. Pilli, J. E. de Carvalho and D. Russowsky, Med. Chem. Commun., 2018, 9, 1553
    DOI: 10.1039/C8MD00270C

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