SCHEDULED MAINTENANCE
Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates†
Loredana
Maiuolo, 
*a
Giordana
Feriotto,
b
Vincenzo
Algieri,
a
Monica
Nardi,
ac
Beatrice
Russo,
a
Maria Luisa
Di Gioia,
d
Emilia
Furia,
a
Matteo Antonio
Tallarida,
a
Carlo
Mischiati
e
and
Antonio
De Nino
*a
*a
Giordana
Feriotto,
b
Vincenzo
Algieri,
a
Monica
Nardi,
ac
Beatrice
Russo,
a
Maria Luisa
Di Gioia,
d
Emilia
Furia,
a
Matteo Antonio
Tallarida,
a
Carlo
Mischiati
e
and
Antonio
De Nino
*a
Abstract
A series of ketonitrones derived from isatin and indanone (INs) were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Then, the antioxidant properties of these substrates were measured by the DPPH test to report their biological activity in terms of their spin trapping action. In particular, one substrate has showed very high biological and scavenging activity, probably due to the strong correlation between its spin trapping activity and structure.
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