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Issue 18, 2018
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Microfluidic-based vascularized microphysiological systems

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Abstract

Microphysiological systems have emerged in the last decade to provide an alternative to in vivo models in basic science and pharmaceutical research. In the field of vascular biology, in particular, there has been a lack of a suitable in vitro model exhibiting a three-dimensional structure and the physiological function of vasculature integrated with organ-on-a-chip models. The rapid development of organ-on-a-chip technology is well positioned to fulfill unmet needs. Recently, functional integration of vasculature with diverse microphysiological systems has been increasing. This recent trend corresponds to emerging research interest in how the vascular system contributes to various physiological and pathological conditions. This innovative platform has undergone significant development, but adoption of this technology by end-users and researchers in biology is still a work in progress. Therefore, it is critical to focus on simplification and standardization to promote the distribution and acceptance of this technology by the end-users. In this review, we will introduce the latest developments in vascularized microphysiological systems and summarize their outlook in basic research and drug screening applications.

Graphical abstract: Microfluidic-based vascularized microphysiological systems

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Publication details

The article was received on 20 Mar 2018, accepted on 31 Jul 2018 and first published on 09 Aug 2018


Article type: Critical Review
DOI: 10.1039/C8LC00285A
Citation: Lab Chip, 2018,18, 2686-2709
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    Microfluidic-based vascularized microphysiological systems

    S. Lee, J. Ko, D. Park, S. Lee, M. Chung, Y. Lee and N. L. Jeon, Lab Chip, 2018, 18, 2686
    DOI: 10.1039/C8LC00285A

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