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Issue 12, 2018
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Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

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Abstract

Study of extracellular vesicles (EVs), particularly exosomes, holds significant promise; however, it is technically challenging to define these small and molecularly diverse nanovesicles. With intrinsic molecular payload and biodegradability, molecular engineering of exosomes opens new avenues for mediating cellular responses and developing novel nano-delivery systems in precision therapeutics. Microfluidic lab-on-chip technology is playing pivotal roles in this emerging field. In this review, we have examined scientific advancements of microfluidic technology for engineering exosomes and assessed future applications and perspectives in developing precision therapeutics; this can serve the community via identification of potential new research areas or technologies that are urgently needed in precision therapeutics.

Graphical abstract: Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

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Article information


Submitted
08 Mar 2018
Accepted
04 May 2018
First published
07 May 2018

Lab Chip, 2018,18, 1690-1703
Article type
Perspective
Author version available

Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

Q. Zhu, M. Heon, Z. Zhao and M. He, Lab Chip, 2018, 18, 1690
DOI: 10.1039/C8LC00246K

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