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An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes

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Abstract

Development of new chemical processes with simplified reaction systems and work-up procedures is a challenging task. Although ionic liquids are a class of potential multifunctional compounds to simplify traditional chemical processes, their rational design is difficult due to complex interactions. In this work, a proof-of-concept strategy has been proposed to achieve an integration of high-throughput preparation of ionic liquids and in situ screening of their reaction-promoting performance in 96-well plates. The integrated approach then enables a facile identification of optimal ionic liquids from a 400-ionic liquid candidate pool to act as the solvent, the catalyst and the separating assistant, simultaneously, for carbonyl-azide cycloaddition reactions. Merits of the ionic liquids-based processes have been demonstrated not only in the convenient and efficient synthesis of 1,2,3-triazolyl compounds but also in the discovery of a new reaction for the chemical post-modification of free peptides.

Graphical abstract: An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes

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Publication details

The article was received on 06 Oct 2018, accepted on 30 Nov 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8GC03119C
Citation: Green Chem., 2019, Advance Article
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    An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes

    A. Zhu, L. Li, C. Zhang, Y. Shen, M. Tang, L. Bai, C. Du, S. Zhang and J. Wang, Green Chem., 2019, Advance Article , DOI: 10.1039/C8GC03119C

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