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Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions

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Abstract

A four-component procedure for the preparation of substituted quinazolines from anilines, aromatic aldehydes and ammonium iodide is described. The C–H bond ortho to the amino group in anilines was directly functionalized under metal-free conditions. Two aldehydes were involved in this reaction and ammonium iodide was used as one of the nitrogen sources. This reaction provides a strategy for the facile construction of substituted quinazolines from simple anilines and other readily available reactants.

Graphical abstract: Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions

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Publication details

The article was received on 21 Aug 2018, accepted on 15 Oct 2018 and first published on 17 Oct 2018


Article type: Communication
DOI: 10.1039/C8GC02654H
Citation: Green Chem., 2018, Advance Article
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    Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions

    J. Chen, D. Chang, F. Xiao and G. Deng, Green Chem., 2018, Advance Article , DOI: 10.1039/C8GC02654H

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