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Issue 19, 2018
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Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

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Abstract

A study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m−3 day−1 in a mixer mill to 3395 kg m−3 day−1 in a twin screw extruder.

Graphical abstract: Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

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Publication details

The article was received on 01 Jul 2018, accepted on 23 Aug 2018 and first published on 18 Sep 2018


Article type: Communication
DOI: 10.1039/C8GC02036A
Citation: Green Chem., 2018,20, 4443-4447
  • Open access: Creative Commons BY license
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    Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

    Q. Cao, J. L. Howard, D. E. Crawford, S. L. James and D. L. Browne, Green Chem., 2018, 20, 4443
    DOI: 10.1039/C8GC02036A

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