Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 19, 2018
Previous Article Next Article

Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

Author affiliations

Abstract

A study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m−3 day−1 in a mixer mill to 3395 kg m−3 day−1 in a twin screw extruder.

Graphical abstract: Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

Back to tab navigation

Supplementary files

Article information


Submitted
01 Jul 2018
Accepted
23 Aug 2018
First published
18 Sep 2018

This article is Open Access

Green Chem., 2018,20, 4443-4447
Article type
Communication

Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

Q. Cao, J. L. Howard, D. E. Crawford, S. L. James and D. L. Browne, Green Chem., 2018, 20, 4443
DOI: 10.1039/C8GC02036A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements