Sahar Roshandel, Suresh C. Suri, Jacob C. Marcischak, Golam Rasul and G. K. Surya Prakash
Green Chem., 2018,20, 3700-3704
DOI:
10.1039/C8GC01516C,
Communication
We report a microwave-assisted catalyst and solvent free synthesis of 1,2,3-triazoles through the cycloaddition of trimethylsilylazide and acetylenes. Utilization of a thermally stable azide source, elimination of a metal catalyst, solvent or any additives, and a convenient isolation procedure result in an overall greener approach to access 1,2,3-triazoles on a practical scale with good to excellent yields (55–99%).