Issue 8, 2018

Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol

Abstract

The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on a large scale. As a proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in the ortho-position using pressurized CO2 (∼30–40 bar) catalyzed by ortho-benzoic acid decarboxylases with up to 68% conversion. Optimization studies revealed tight pH-control and enzyme stability as the most important determinants.

Graphical abstract: Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol

Supplementary files

Article information

Article type
Communication
Submitted
01 Jan 2018
Accepted
08 Mar 2018
First published
03 Apr 2018
This article is Open Access
Creative Commons BY license

Green Chem., 2018,20, 1754-1759

Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol

K. Plasch, G. Hofer, W. Keller, S. Hay, D. J. Heyes, A. Dennig, S. M. Glueck and K. Faber, Green Chem., 2018, 20, 1754 DOI: 10.1039/C8GC00008E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements