A KI-mediated radical anti-Markovnikov addition of simple ketones/esters to unactivated alkenes

Yunfei Tian; Changqing Sun; Ren Xiang Tan; Zhong-Quan Liu

doi:10.1039/C7GC03745G

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A KI-mediated radical anti-Markovnikov addition of simple ketones/esters to unactivated alkenes†

Yunfei Tian,^a Changqing Sun,^a Ren Xiang Tan^b and Zhong-Quan Liu

*^ab

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* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
E-mail: liuzhq@lzu.edu.cn

^b State Key Laboratory Cultivation Base for TCM Quality and Efficacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

Abstract

A KI-mediated radical anti-Markovnikov addition of simple ketones and esters to unactivated alkenes was developed. Through this strategy, a wide range of complex carbonyl compounds can be conveniently synthesized in high selectivities. In addition, this method features high atom-economy and is transition-metal free, operationally simple and environmentally benign.

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Article information

DOI: https://doi.org/10.1039/C7GC03745G
Article type: Communication
Submitted: 13 Dec 2017
Accepted: 05 Jan 2018
First published: 08 Jan 2018

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Green Chem., 2018,20, 588-592

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A KI-mediated radical anti-Markovnikov addition of simple ketones/esters to unactivated alkenes

Y. Tian, C. Sun, R. X. Tan and Z. Liu, Green Chem., 2018, 20, 588 DOI: 10.1039/C7GC03745G

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Green Chemistry

A KI-mediated radical anti-Markovnikov addition of simple ketones/esters to unactivated alkenes†

Abstract

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A KI-mediated radical anti-Markovnikov addition of simple ketones/esters to unactivated alkenes

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