Low intake of digestible carbohydrates ameliorates the duodenal absorption of carbohydrates in mice with glucose metabolic disorders induced by sucralose

Abstract

In the current study, the protective effects of diets with low digestible carbohydrates (LDCs) on plasma glucose, plasma fasting insulin, sweet taste receptors, glucose transporters and absorption of carbohydrates in mice that consume sucralose were evaluated. Sucralose (0.4 g L⁻¹) was administered to mice to induce glucose metabolic disorders. The experimental groups were treated with different LDC contents but with the same energy as the normal-chow group. A pair group fed the highest digestible carbohydrate content was designed to illustrate the effect of digestible carbohydrate content on glucose metabolic disorders. Prolonged administration of sucralose led to metabolic dysfunction that was characterized by a significant increase in plasma glucose, insulin resistance, sweet taste receptors, glucose transporters and absorption of carbohydrates. Treatment with LDC feed positively modulated the altered parameters in a dose dependent manner, suggesting the overall beneficial effects of LDC feed on sucralose associated detrimental changes.