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Expression enhancement in brown adipose tissue of genes related to thermogenesis and mitochondrial dynamics after administration of pepsin egg white hydrolysate

Abstract

Nutritional compounds could be a safe and less expensive treatment for complications associated to obesity and metabolic syndrome (MetS). The aim of this study was to investigate the mechanism of action and the target tissues of a pepsin egg white hydrolysate (EWH) which had previously demonstrated to improve some obesity-related disorders on high-fat/high-glucose rat model. Wistar rats were used and divided in 3 groups: Control group (C), High-fat/high-glucose diet (MS) and high-fat/high-glucose diet + EWH (MSH). The rats were fed during 20 weeks and the EWH was administrated from week 9th. At the end of the study, white adipose tissue (WAT), brown adipose tissue (BAT) and muscle samples were collected for RT-qPCR analyses and immunohistochemistry. Our results showed a gene expression enhancement in BAT of genes related to thermogenesis and mitochondrial dynamics. Mitochondrial DNA quantification and immunohistochemistry results showed an increase of mitochondrial content in this tissue. In conclusion, our results show the potential metabolic effect of this pepsin EWH by enhancing mitochondria proliferation and gene expression related to thermogenesis in BAT. EWH could be used as functional food ingredient able to increase energy expenditure and counteract obesity-related MetS in a chronically obese society.

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Publication details

The article was received on 05 Sep 2018, accepted on 06 Nov 2018 and first published on 06 Nov 2018


Article type: Paper
DOI: 10.1039/C8FO01754A
Citation: Food Funct., 2018, Accepted Manuscript
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    Expression enhancement in brown adipose tissue of genes related to thermogenesis and mitochondrial dynamics after administration of pepsin egg white hydrolysate

    S. Moreno-Fernández, M. Garcés-Rimón, J. A. Uranga, J. Astier, J. Landrier and M. MIGUEL, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO01754A

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