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Licochalcone A inhibits invasive potential of human glioma cells by targeting MEK/ERK and ADAM9 signaling pathways

Abstract

Licochalcone A (LicA) has been reported to possess antitumor properties. However, its effect on human glioma cells remains unknown. In this study, we observed that LicA significantly suppressed ADAM9 expression and cell migration and invasion activities of human glioma cells (M059K, U-251 MG, and GBM8901) and exhibited no cell cytotoxicity. Human proteinase antibody array and immunoblot analysis indicated that the LicA treatment inhibited the expression of ADAM9 protein in human glioma cells. Recombinant human ADAM-9 (Rh-ADAM9) treatment significantly reversed the LicA-induced reduction in the ADAM9 level and the cell migration and invasion activities of human glioma cells. Additionally, the phosphorylation/activation of the mitogen-activated protein kinase kinase (MEK)-extracellularly responsive kinases (ERK) signaling pathway was significantly suppressed in LicA-treated human glioma cells. Cotreatment with LicA and PD98059 synergistically inhibited ADAM9 expression, cell migration, and cell invasion, which suggested that the MEK-ERK signaling pathway was involved in LicA-induced inhibition of ADAM9 expression and invasion activity of human glioma cells. These findings are the first evidence of the LicA’s anti-invasive properties against human glioma cells.

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Publication details

The article was received on 18 Aug 2018, accepted on 29 Oct 2018 and first published on 30 Oct 2018


Article type: Paper
DOI: 10.1039/C8FO01643G
Citation: Food Funct., 2018, Accepted Manuscript
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    Licochalcone A inhibits invasive potential of human glioma cells by targeting MEK/ERK and ADAM9 signaling pathways

    C. Huang, S. Yang, H. Chiou, W. Hsu, J. Hsu, C. Liu and Y.-H. Hsieh, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO01643G

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