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Redox balance of healthy Brazilian adults is associated with GPX1 Pro198Leu and -602 A/G polymorphisms, selenium status, anthropometric and lifestyle parameters

Abstract

Purpose: Considering that oxidative stress is implicated in the pathogenesis and progression of different health conditions, we aimed to evaluate whether redox balance of a healthy Brazilian population is associated with GPX1 polymorphisms, selenium status, lipid profile, and anthropometric and lifestyle parameters. Methods: 343 healthy adults were assessed for redox balance markers [glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity, malondialdehyde (MDA) and oxygen radical absorption capacity (ORAC)]; genotyped for the polymorphisms GPX1 Pro198Leu (rs1050450), -602 A/G (rs3811699) and Arg5Pro (rs8179169); evaluated for selenium biomarkers (plasma, erythrocyte, and urine) and intake; and lipid profile. Anthropometric (BMI) and lifestyle data (physical activity, current smoking habit and alcohol consumption) were collected. Multivariable regression models were applied to investigate the possible associations. Results: Although there were no differences in GPx activity according to GPX1 Pro198Leu and -602A/G polymorphisms, this redox balance marker was positively associated with erythrocyte selenium and negatively with the presence of minor allele of Pro198Leu. SOD activity was positively associated with the presence of minor allele for these polymorphisms. ORAC showed the same pattern among Leu and G carriers and was positively associated with Leu allele presence, BMI and alcohol intake. MDA was only associated negatively with male sex and plasma selenium. Conclusions: Our findings suggest that redox balance of a Brazilian healthy population is associated with GPX1 polymorphisms (Pro198Leu and -602A/G), selenium status, BMI, sex, smoking habit and alcohol consumption.

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Publication details

The article was received on 14 Aug 2018, accepted on 13 Sep 2018 and first published on 14 Sep 2018


Article type: Paper
DOI: 10.1039/C8FO01621F
Citation: Food Funct., 2018, Accepted Manuscript
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    Redox balance of healthy Brazilian adults is associated with GPX1 Pro198Leu and -602 A/G polymorphisms, selenium status, anthropometric and lifestyle parameters

    K. G. Almondes, B. R. Cardoso, C. Cominetti, N. N. Nogueira, D. Marreiro, T. F. Oliveira, A. P. Loureiro and S. M. Cozzolino, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO01621F

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