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Issue 11, 2018
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Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil

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Abstract

Leaf fractions of Garcinia brasiliensis were evaluated concerning their antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties, and the most active fraction was then fully characterized regarding its phenolic composition using HPLC-DAD-ESI/MSn. The ethyl acetate fraction from partitioning of the methanolic leaf extract revealed a strong antioxidant activity that was comparable to Trolox, the positive control. This fraction was also able to show a significant antimicrobial activity against Gram-positive and Gram-negative bacteria and the fungus Candida albicans. However, the dichloromethane fraction was found to present the highest anti-inflammatory (83 ± 9 μg mL−1) and cytotoxic activities, thus presenting slight toxicity using a non-tumor cell line. Regarding the phenolic profile, the ethyl acetate fraction presented twelve flavonoids, with morelloflavone-7′′-O-glucoside (52.1 ± 0.4 mg g−1) and gardinia biflavonoid 2a glucoside (27.5 ± 0.2 mg g−1) being the major compounds identified. These results indicate that leaves of G. brasiliensis might be a potential source of natural biomolecules for pharmaceutical and medicinal applications.

Graphical abstract: Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil

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Publication details

The article was received on 22 Jul 2018, accepted on 27 Aug 2018 and first published on 18 Sep 2018


Article type: Paper
DOI: 10.1039/C8FO01474D
Citation: Food Funct., 2018,9, 5621-5628
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    Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil

    R. A. Zan, Â. Fernandes, S. Jedoz, T. Oludemi, R. C. Calhelha, T. C. S. P. Pires, M. J. Alves, R. C. C. Martins, L. Barros and I. C. F. R. Ferreira, Food Funct., 2018, 9, 5621
    DOI: 10.1039/C8FO01474D

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