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DHA-Phospholipids (DHA-PL) and EPA-Phospholipids (EPA-PL) Prevents Intestinal Dysfunction Induced by Chronic Stress

Abstract

Stress exposure can increase the appearance of intestinal dysfunction. DHA and EPA has been shown to possess significant anti-inflammation and immuno-enhancement bioactivities. The aim of the study was to investigate whether different forms of DHA or EPA would affect intestinal barriers (inclucing intestinal epithelium integrity and immunity responses, gut microbiota and its metabolites) in mice under chronic stress, and might therefore prevent stress induced intestinal dysfunction. Chronic stress caused a series of anomalies in intestine, including decreased faecal water content, increased pro-inflammatory cytokines (IFN-γ, TNF-α, IL-1β and IL-6), reduced expression levels of ZO-1, Occludin and E-cadherin, aberrant microbiota composition (especially Roseburia spp., Prevotella spp., Bifidobacteria and Lactobacilli) and its metabolites, mainly LPS, acetic acid, propionic acid and butyric acid. Our data indicated that both DHA-PL and EPA-PL counteracted these adverse effects effectively. In conclusion, DHA-PL and EPA-PL may effectively protect mice against intestinal dysfunction under chronic stress exposure as potential ingredients for functional food.

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Publication details

The article was received on 13 Jul 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Paper
DOI: 10.1039/C8FO01404C
Citation: Food Funct., 2018, Accepted Manuscript
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    DHA-Phospholipids (DHA-PL) and EPA-Phospholipids (EPA-PL) Prevents Intestinal Dysfunction Induced by Chronic Stress

    W. Cao, C. Wang, Y. Chin, X. Chen, Y. Gao, S. Yuan, C. Xue, Y. Wang and Q. Tang, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO01404C

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