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Issue 11, 2018
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Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice

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Abstract

Obesity is a severe public health problem worldwide. Our study aims to assess whether a saponin-enriched extract from the leaves of Boussingaultia gracilis (SBG) could attenuate obesity and its related metabolic disorders in mice and to explore the potential mechanism of this effect. Three-week old male mice were fed with a HFD for 7 weeks followed by a 10-week period in which the mice were supplemented with distilled water or SBG (250 mg per kg bodyweight). We demonstrated that SBG supplementation for 10 weeks mitigated obesity and its complications in diet-induced obesity (DIO) mice, such as reducing the hepatic damage underlying steatosis, modulating lipid metabolism, enhancing adipocyte thermogenesis, restoring insulin sensitivity and glucose homeostasis, and alleviating inflammation status. Finally, we established an untargeted metabolomics approach based on UPLC-MS to profile the metabolic changes in liver tissue and thereby discovered novel potential biomarkers to clarify the mechanisms of action of SBG in treating a mouse model of DIO. Thirty-nine potential biomarkers and five metabolic pathways contributing to the beneficial effect of SBG were discovered and identified.

Graphical abstract: Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice

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Publication details

The article was received on 26 Jun 2018, accepted on 15 Sep 2018 and first published on 28 Sep 2018


Article type: Paper
DOI: 10.1039/C8FO01264D
Citation: Food Funct., 2018,9, 5660-5673
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    Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice

    L. Liu, N. Wang, Y. Ma, Y. Liu and D. Wen, Food Funct., 2018, 9, 5660
    DOI: 10.1039/C8FO01264D

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