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High Dietary Inflammatory Index scores are associated with elevated risk of hepatocellular carcinoma in a Case-Control Study

Abstract

Chronic inflammation and diet play crucial roles in the development of hepatocellular carcinoma (HCC); yet the association between dietary inflammatory potential and risk of HCC has rarely been investigated. This study aimed to examine whether a higher dietary inflammatory index (DII®) score (indicating a pro-inflammatory diet) is associated with an increased risk of HCC in a matched case-control study conducted between September 2013 and October 2017 in South China. A total of 659 cases with newly diagnosed, previously untreated HCC and 659 controls individually matched on age (±3 years) and sex were included in this study. DII scores were computed based on dietary intake collected via a validated 79-item food frequency questionnaire (FFQ) during the one year prior to diagnosis (for cases) or interview (for controls). Logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) between DII score and risk of HCC, adjusted for age, energy intake, body mass index, physical activity, marital status, education, household income, smoking status, and hepatitis B virus (HBV) infection status. Compared with subjects in the lowest DII tertile, subjects in the highest tertile had an elevated risk of HCC (fully adjusted OR: 3.22, 95% CI: 1.30-7.98, P-trend=0.009). In stratified analyses, a significantly positive association was observed only in men, individuals with lower education level, smokers and non-alcohol drinkers. In conclusion, a higher DII score, representing a more inflammatory diet, was associated with an increased risk of HCC, in men, individuals with lower education level, smokers and non-alcohol drinkers.

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Publication details

The article was received on 14 Jun 2018, accepted on 04 Oct 2018 and first published on 05 Oct 2018


Article type: Paper
DOI: 10.1039/C8FO01190G
Citation: Food Funct., 2018, Accepted Manuscript
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    High Dietary Inflammatory Index scores are associated with elevated risk of hepatocellular carcinoma in a Case-Control Study

    X. Wang, A. Fang, P. Chen, G. Liao, Y. Zhang, N. Shivappa, J. R. Hébert, Y. M. Chen and H. L. Zhu, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO01190G

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