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Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives

Abstract

Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related with some of the health benefits described for olive oil intake. We have demonstrated previously that hydroxytyrosol inhibits angiogenesis both in vitro and in vivo. In the present study, we evaluate the anti-angiogenic potential of five hydroxytyrosol derivatives. Three of these derivatives contain a nitro group and they exhibit a much weaker effect than hydroxytyrosol in the tubule formation assay on Matrigel and therfore were not studied further. In contrast, both hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether show more potent inhibitory effects than hydroxytyrosol in both the in vitro tubule formation assay on Matrigel and the in vivo chorioallantoic membrane assay. Additionally, these three compounds had slight pro-apoptotic effects and decreased matrix metalloproteinase-2 levels in cell extracts.

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Publication details

The article was accepted on 30 Jun 2018 and first published on 04 Jul 2018


Article type: Paper
DOI: 10.1039/C8FO01140K
Citation: Food Funct., 2018, Accepted Manuscript
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    Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives

    A. López-Jiménez, E. Gallardo, J. L. Espartero, A. Madrona, A. R. Quesada and M. A. Medina, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO01140K

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