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Anti-Obesity Potential of Rare Sugar D-psicose by Regulating Lipid Metabolism in Rats


D-psicose is a new generation sugar substitute with low calorie value while still offering desirable sweetness. This objective of this study was to investigate the anti obesity potential of D-psicose and possible mechanism using Wistar rats as animal model. Animals were divided into five groups and supplemented with diets containing 5% of different carbohydrates including glucose, fructose, cellulose, D-psicose and control diet for 4 weeks, respectively. After sacrifice, blood lipid profile, tissue morphology and related genes participated in lipid metabolism were analyzed. Results indicated supplementation of D-psicose lead to minimum fat accumulation in rats compared with other carbohydrates. The blood lipid profile and anti-oxidative activity of the rat was also improved. D-psicose can regulate lipid metabolism by increasing lipid metabolism related enzymes such as SDH in serum and liver, and HL in the liver. D-psicose can prevent fat accumulation by suppressing the expression of lipogenesis related gene ACCα, hepatic fatty acid uptake gene including FAS and SREBP-1c gene, while stimulating the expression for fatty acid oxidation related gene including AMPK2α, HSL and PPARα. In conclusion, D-psicose can be a healthy alternative to traditional sweetener.

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Publication details

The article was received on 31 May 2018, accepted on 29 Oct 2018 and first published on 09 Nov 2018

Article type: Paper
DOI: 10.1039/C8FO01089G
Citation: Food Funct., 2018, Accepted Manuscript

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    Anti-Obesity Potential of Rare Sugar D-psicose by Regulating Lipid Metabolism in Rats

    J. Chen, W. Huang, T. Zhang, M. Lu and B. Jiang, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO01089G

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