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Issue 5, 2019
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Anti-obesity potential of rare sugar d-psicose by regulating lipid metabolism in rats

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D-Psicose is a new-generation sugar substitute with a low calorie count and can still offer the desirable sweetness. The objective of this study was to investigate the antiobesity potential of D-psicose and the possible mechanism using Wistar rats as the animal model. The animals were divided into five groups and supplemented with diets containing 5% of different carbohydrates, such as glucose, fructose, cellulose, D-psicose, and a control diet, for 4 weeks. After sacrifice, blood lipid profile, tissue morphology, and related genes participating in lipid metabolism were analyzed. The results indicated that the supplementation by D-psicose leads to minimum fat accumulation in rats when compared with the other carbohydrates. The blood lipid profile and antioxidative activity of the rat were also improved. D-Psicose can regulate lipid metabolism by increasing the lipid-metabolism-related enzymes such as SDH in serum and liver and HL in the liver. D-Psicose can prevent fat accumulation by suppressing the expression of lipogenesis-related gene ACCα and hepatic fatty acid uptake gene (FAS and SREBP-1c), while stimulating the expression for fatty-acid-oxidation-related gene including AMPK2α, HSL, and PPARα. In conclusion, D-psicose can be considered to be a healthy alternative to traditional sweeteners.

Graphical abstract: Anti-obesity potential of rare sugar d-psicose by regulating lipid metabolism in rats

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Publication details

The article was received on 31 May 2018, accepted on 29 Oct 2018 and first published on 09 Nov 2018

Article type: Paper
DOI: 10.1039/C8FO01089G
Food Funct., 2019,10, 2417-2425

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    Anti-obesity potential of rare sugar D-psicose by regulating lipid metabolism in rats

    J. Chen, W. Huang, T. Zhang, M. Lu and B. Jiang, Food Funct., 2019, 10, 2417
    DOI: 10.1039/C8FO01089G

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