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Changes in metabolites profile of breast milk over lactation stages and their relationship with dietary intake in Chinese: HPLC-QTOFMS based metabolomic analysis

Abstract

The aim of the present study was to comprehensively evaluate changes in metabolites profile of breast milk over lactation stages and their relationship with dietary intake in Chinese by HPLC-QTOFMS based metabolomic analysis. Colostrum, transitional milk and mature milk of thirty healthy lactating women were collected for analysis. Eighty-four differential metabolites over lactation stages were identified, including 12 fatty acyls, 15 glycerolipids, 23 glycerophospholipids, 7 sphingolipids, 7 vitamins, 5 nucleotides-related metabolites, 2 amino acids, 1 amino acid derivate, 9 dipeptides, 1 steroid hormones, 1 energy-related metabolite and 1 amine. Partial least square regression analysis indicated that metabolites profiles of colostrum, transitional milk and mature milk have a strong relationship with dietary intake (R2 values were 0.92, 0.87 and 0.74, respectively). However, among the 84 differential metabolites over lactation stages, only two showed a strong relationship with dietary intake: 1,24,25-(OH)3 vitamin D3 was positively correlated with dietary intake of meat and eggs, protein and fat; 11β-hydroxyprogesterone was negative correlated with dietary intake of fruit and carbohydrate. After adjusting for dietary intake, the variation trend of all the 84 differential metabolites over lactation stages remained unchanged. In conclusion, 84 differential metabolites in breast milk of Chinese over lactation stages were identified, and their variation trend was independent of dietary intake. These metabolites were partially different from those identified in previous metabolomic studies of western population. The present study is quite meaningful for understanding the variation of nutrition requirements by Chinese infants at different developmental stages and manufacturing optimal infant formula for Chinese.

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Publication details

The article was received on 21 May 2018, accepted on 05 Sep 2018 and first published on 06 Sep 2018


Article type: Paper
DOI: 10.1039/C8FO01005F
Citation: Food Funct., 2018, Accepted Manuscript
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    Changes in metabolites profile of breast milk over lactation stages and their relationship with dietary intake in Chinese: HPLC-QTOFMS based metabolomic analysis

    K. Li, J. Jiang, H. Xiao, K. Wu, C. Qi, J. Sun and D. Li, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO01005F

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