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Vanillic acid activates thermogenesis in brown and white adipose tissue


Anthocyanins have a positive effect on resistant obesity, however they cannot usually be absorbed directly but, instead, are metabolized by gut microbiota. This study will examine the effects and the mechanism of vanillic acid on prevent obesity induced by diet, which is one of the anthocyanins metabolites. We fed C57BL/6J mice vanillic acid supplements in a high fat and high fructose diet for 16 weeks. Body weight, fat pat weight, food and water intake were monitored. Glucose homeostasis was assessed with a glucose or insulin tolerance test. The sizes of adipose cells and lipid droplets were analyzed by histology staining, while genes and proteins expression were analyzed by quantitative real-time PCR, western blot and tissue-blot immunoassay. The results demonstrated that vanillic acid contributed to the reduction of body weight gain, improved glucose tolerance and insulin resistant, and kept body temperature. Furthermore, vanillic acid was found to promote thermogenesis and mitochondrial synthesis of brown adipose tissue and inguinal white adipose tissue. This study demonstrated that vanillic acid could prevent obesity by activating BAT thermogenesis and the promotion of inguinal WAT browning.

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Publication details

The article was received on 17 May 2018, accepted on 29 Jun 2018 and first published on 04 Jul 2018

Article type: Paper
DOI: 10.1039/C8FO00978C
Citation: Food Funct., 2018, Accepted Manuscript
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    Vanillic acid activates thermogenesis in brown and white adipose tissue

    X. Han, J. Guo, Y. You, M. Yin, J. Liang, C. Ren, Z. Jicheng and W. Huang, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00978C

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