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Screening of ordinary commercial varieties of apple fruits under different storage conditions for their potential vascular and metabolic protective properties

Abstract

Epidemiological studies reported that apple consumption was associated to a decrease of cardiovascular and metabolic dysfunction, probably due to the polyphenols and fibers contained in this fruit. Storage conditions and genetic origin of apples have been reported to influence their content and, as a consequence, their pharmacological properties. Present study evaluated the influence of varieties and storage conditions of traditional and highly appreciated apples including Gala, Golden Delicious, Granny Smith and Pink Lady varieties after harvest and stored in classic cold conditions, under controlled atmosphere, or extreme ultra-low oxygen conditions. Thus, a multi-parametric screening on cell models associated to vascular and metabolic dysfunctions - such as endothelial and smooth muscle cells, hepatocytes, adipocytes and macrophages - in relation to apple polyphenol content has been developed. This strategy demonstrated that, over all, peeled apple samples exhibited a vascular tropism and acted mainly on proliferation and oxidative stress on endothelial and smooth muscle cells. Apple extracts appeared to be less effective on adipocytes and macrophages, but they exhibited antioxidant properties in hepatocytes. Among the varieties, Gala and Golden Delicious were the most efficient against the processes involved in the development of atherosclerosis. Concerning storage condition, most of the apple varieties were more efficient under harvest condition; while they could not can be discriminated neither under all other cold conditions nor the concentration used except for the Gala samples. Interestingly, pharmacological properties were associated with polyphenol profiles of freeze dried flesh apple powder. The present report revealed the potential use of some apple extracts as effective food supplements or nutraceuticals for the prevention and/or management of cardiovascular and metabolic diseases.

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Publication details

The article was received on 16 May 2018, accepted on 02 Oct 2018 and first published on 03 Oct 2018


Article type: Paper
DOI: 10.1039/C8FO00967H
Citation: Food Funct., 2018, Accepted Manuscript
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    Screening of ordinary commercial varieties of apple fruits under different storage conditions for their potential vascular and metabolic protective properties

    R. SOLETI, G. Hilairet, P. Mallegol, C. Dourgia, M. Frifra, M. C. Guillou, A. Gacel, S. Guyot, P. Pignon, L. Basset, Y. Cadot, J. P. Renou, M. Orsel and R. Andriantsitohaina, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00967H

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