The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging
A.
Cortés-Martín, 
a
R.
García-Villalba,
a
A.
González-Sarrías,
a
M.
Romo-Vaquero,
a
V.
Loria-Kohen,
b
A.
Ramírez-de-Molina,
b
F. A.
Tomás-Barberán,
a
M. V.
Selma
a
and
J. C.
Espín
*a
a
R.
García-Villalba,
a
A.
González-Sarrías,
a
M.
Romo-Vaquero,
a
V.
Loria-Kohen,
b
A.
Ramírez-de-Molina,
b
F. A.
Tomás-Barberán,
a
M. V.
Selma
a
and
J. C.
Espín
*a
Abstract
Understanding individuals’ response to dietary bioactives is crucial for personalized nutrition. We report here for the first time in a Caucasian cohort (5–90 years, n = 839) that aging is the main factor that determines the gut microbiota involved in the ellagic acid–ellagitannin metabolism (urolithin metabotypes), with potential consequences for human health.
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