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Issue 9, 2018
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β-Hydroxy-β-methylbutyrate modulates lipid metabolism in adipose tissues of growing pigs

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Abstract

Background: The effects and roles of the leucine (Leu) metabolite β-hydroxy-β-methylbutyrate (HMB) in lipid metabolism in adipose tissues of pigs are still unknown. Objectives: This study was conducted to investigate the effects of excess Leu versus HMB on growth, carcass traits, and lipid metabolism in adipose tissues of growing pigs. Methods and results: Compared to control, the Leu/HMB group significantly increased/reduced weight of total fat mass, respectively, with a concurrent increase of serum adiponectin concentration (P < 0.05). Moreover, dietary HMB supplementation regulated the expression of genes involved in adipose tissue function, accompanied by increases/decreases in the phosphorylation of AMPKα/mTOR in perirenal adipose tissue, respectively (P < 0.05). Serum IL-15 concentration and the mRNA abundance of IL-15, PGC-1α, and NRF-1 were also increased in the HMB group (P < 0.05). Conclusions: HMB supplementation can regulate adipose tissue function including fatty acid oxidation, lipolysis, and adipokine secretion. These effects may be partly mediated by AMPKα-mTOR pathway and associated with mitochondrial biogenesis, the AMPK-PGC-1α axis, and myokines secreted by muscle tissues.

Graphical abstract: β-Hydroxy-β-methylbutyrate modulates lipid metabolism in adipose tissues of growing pigs

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Article information


Submitted
07 May 2018
Accepted
15 Aug 2018
First published
16 Aug 2018

Food Funct., 2018,9, 4836-4846
Article type
Paper

β-Hydroxy-β-methylbutyrate modulates lipid metabolism in adipose tissues of growing pigs

Y. Duan, L. Zhang, F. Li, Q. Guo, C. Long, Y. Yin, X. Kong, M. Peng and W. Wang, Food Funct., 2018, 9, 4836
DOI: 10.1039/C8FO00898A

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