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Freshwater clam extract reduces liver injury by lowering cholesterol accumulation, improving dysregulated cholesterol synthesis and alleviating inflammation in high-fat, high-cholesterol and cholic acid diet-induced steatohepatitis in mice

Abstract

Freshwater clam (Corbicula fluminea) is a traditional liver-protective food in Asia. Recent studies have renewed attention on high cholesterol accumulation and dysregulated cholesterol synthesis in liver as a critical factor in the progression of nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH). In this study, we investigated the protective effects of freshwater clam extract (FCE) and its fat fraction (FCE oil) on high-fat, high-cholesterol and cholic acid (HFHC) diet-induced lean steatohepatitis in mice. Mice were fed a HFHC diet containing FCE or FCE oil for 6 weeks. FCE, but not FCE oil, feeding reduced liver injury as indicated by decreased plasma alanine aminotransferase activity. Liver total cholesterol accumulation was reduced after FCE and FCE oil treatment. Accumulations of squalene and desmosterol, the precursors of cholesterol, in liver were reduced by FCE but not by FCE oil. The caspase-1 (p10) and interleukin (IL)-1β (p17) protein expressions in liver were suppressed by both FCE and FCE oil. Therefore, FCE may act as functional food that can reduce steatohepatitis and liver injury by reducing cholesterol accumulation, improving dysregulated cholesterol synthesis and attenuating inflammation.

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Publication details

The article was received on 02 May 2018, accepted on 10 Aug 2018 and first published on 11 Aug 2018


Article type: Paper
DOI: 10.1039/C8FO00851E
Citation: Food Funct., 2018, Accepted Manuscript
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    Freshwater clam extract reduces liver injury by lowering cholesterol accumulation, improving dysregulated cholesterol synthesis and alleviating inflammation in high-fat, high-cholesterol and cholic acid diet-induced steatohepatitis in mice

    H.T. Yao, P. Lee, C. Lii, Y. Liu and S. Chen, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00851E

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