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Protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior

Abstract

The gastroprotective effect of Ocimum basilicum L. (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcer in mice and its ameliorative effect on behavioral alterations was determined. Pretreatment with OBHE (100 or 200 mg/kg) or misoprostol (50 µg/kg) alleviated the aspirin-induced oxidative stress by significantly decreasing (p ˂ 0.001) gastric MDA (by 49, 51 and 52%), NO (21, 28 and 29%) and H2O2 (24, 42 and 45%), as well as by markedly increasing gastric GSH (41, 61 and 70%), GSH-Px (21, 32 and 34 %), GST (33, 63 and 70%), GR (90, 99 and 112 %) and CAT (167, 211 and 267%), respectively, as compared to the aspirin-ulcerated group. A significant decrease (p ˂ 0.001) in proinflammatory mediator TNF-α (21, 53 and 53%) and IL-6 (29, 30 and 31%), along with a marked increase in PGE-2 levels (22, 135 and 200%) and IL-4 (64, 81 and 104%) were evident in the groups treated with OBHE or misoprostol, respectively. Meanwhile, OBHE and misoprostol induced a significant decrease (p ˂ 0.001) in the freezing time (53, 56 and 64%), and the grooming time (by 25, 43 and 44%), respectively, as compared to aspirin group. The higher dose of OBHE and misoprostol produced 76% and 79% gastroprotective effect against aspirin. This study provides evidence that OBHE confers anxiolytic, antioxidant and anti-inflammatory prophylactic effects in aspirin-induced gastric ulcer. GC/MS was used for characterization of OBHE components. Based on the findings of this study, basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers, a common problem resulting from the use of aspirin.

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Publication details

The article was received on 19 Mar 2018, accepted on 11 Jul 2018 and first published on 12 Jul 2018


Article type: Paper
DOI: 10.1039/C8FO00538A
Citation: Food Funct., 2018, Accepted Manuscript
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    Protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior

    E. Abd El-Ghffar, E. Al-Sayed, S. Shehata, O. Eldahshan and T. Efferth, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00538A

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