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Issue 6, 2018
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The protective effects of selenium-enriched Spirulina platensis on chronic alcohol-induced liver injury in mice

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Abstract

The aim of this study was to investigate the protective effect and mechanism of selenium-enriched Spirulina platensis (S. platensis) on chronic alcohol-induced liver injury. Selenium incubation raises the nutrition quality of S. platensis by absorption enhancement of functional elements. Our results demonstrated that the effective dose of selenium-enriched S. platensis on HL7702 cells treated with alcohol was 200 μg ml−1, containing 20% selenium. Selenium-enriched S. platensis could raise the cell survival rate by decreasing the expression of p53, Caspase3, LC3, and Caspase1 and by increasing the expression of p70s6k. In vivo experiments, where mice were pretreated with selenium-enriched S. platensis, exhibited obvious inhibition of the liver function index and this pretreatment enhanced the activity of GSH-Px and SOD in alcohol induced mice. In summary, our results indicate that the protective mechanism of selenium-enriched S. platensis on chronic alcoholic liver injury is associated with the activity enhancement of antioxidant enzymes and immunity, the inhibition of DNA damage and apoptosis, accompanied with autophagy and pyroptosis.

Graphical abstract: The protective effects of selenium-enriched Spirulina platensis on chronic alcohol-induced liver injury in mice

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Publication details

The article was received on 13 Mar 2018, accepted on 18 May 2018 and first published on 24 May 2018


Article type: Paper
DOI: 10.1039/C8FO00477C
Citation: Food Funct., 2018,9, 3155-3165

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    The protective effects of selenium-enriched Spirulina platensis on chronic alcohol-induced liver injury in mice

    X. Fu, Z. Zhong, F. Hu, Y. Zhang, C. Li, P. Yan, L. Feng, J. Shen and B. Huang, Food Funct., 2018, 9, 3155
    DOI: 10.1039/C8FO00477C

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