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Diet induced maternal obesity affects offspring gut microbiota, which persists into young adulthood.

Abstract

Accumulating evidence suggests that diets could shape the host gut microbiome composition. Here, we investigated the effects of maternal high fat diet (HFD) consumption on offspring gut microbiota and serum profile, and attempted to explore the beneficial roles of maternal probiotics intervention. Female C57BL/6J mice were fed the normal diet, HFD or HFD with daily probiotics (B. breve DM8310, L. acidophilus DM8302, L. casei DM8121 and S. thermophilus DM8309) gavage for 6 weeks prior to breeding and throughout gestation and lactation. HFD dams produced pups had higher levels of total cholesterol (TC), low-density lipoprotein (LDL), glucose, insulin and leptin compared to pups of chow-fed dams. Maternal probiotics intervention decreased the lipid levels in all pups and also decreased glucose, insulin and leptin levels in adult female pups when compared with those in maternal HFD-fed female pups, to the levels similar to the pups of chow-fed dams. In line with these plasma changes, maternal HFD persistently altered the composition of the offspring gut microbiota in a sex specific way. Maternal probiotics intervention could ameliorate the offspring gut microbiota dysbiosis. Better intervention effects for the females at adulthood were observed. In conclusion, maternal HFD induced offspring gut microbiota dysbiosis and metabolic disorder could persist into adulthood. Maternal prebiotics intervention negated the detrimental effects of maternal HFD on gut microbiota and metabolism in a sex specific way.

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Publication details

The article was received on 09 Mar 2018, accepted on 11 Jul 2018 and first published on 11 Jul 2018


Article type: Paper
DOI: 10.1039/C8FO00444G
Citation: Food Funct., 2018, Accepted Manuscript
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    Diet induced maternal obesity affects offspring gut microbiota, which persists into young adulthood.

    Y. Guo, Z. Wang, L. Chen, L. Tang, S. Wen, Y. Liu and J. Yuan, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00444G

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