Jump to main content
Jump to site search


Borago officinalis seed oil (BSO), a natural source of omega-6 fatty acids, attenuates fat accumulation by activating peroxisomal beta-oxidation both in C. elegans and in diet-induced obese rats

Abstract

Obesity is a medical condition with increasing prevalence, characterized by an accumulation of excessive fat that could be improved with the use of some bioactive compounds. However, many of these compounds with in vitro activity fail to respond in vivo probably due to the sophistication of the physiologic energy regulatory networks. In this context, C. elegans has emerged as a plausible model for the identification and characterization of the effect of such compounds on fat storage in a complete organism. However, the results obtained in such a simple model are not easily extrapolated to more complex organisms such as mammals, which hinder its application in the short term. Therefore, it is necessary to obtain new experimental data about the evolutionary conservation of the mechanisms of fat loss between worms and mammals. Previously, we found that some omega-6 fatty acids promote fat-loss in C. elegans by upregulation of peroxisomal fatty acids ß-oxidation in an omega-3 independent manner. In this work, we prove that the omega-6 fatty acids effects on worms are also shown when they are supplemented in a natural omega-6 source (borage seed oil, BSO). Additionally, we explore the anti-obesity effects of two doses of BSO in a diet-induced obesity rat model, validating the upregulation of peroxisomal fatty acids ß-oxidation. The supplementation with BSO significantly reduces body weight gain and energy efficiency and prevents white adipose tissue accumulation without affecting food intake. Moreover, BSO also increases serum HDL-cholesterol levels, improves insulin resistance and promotes Cebpa downregulation, an adipogenesis-related gene. Therefore, we conclude that the effects of omega-6 fatty acids are highly conserved between worms and obese-induced mammals, so these compounds could be considered to treat or prevent obesity-related disorders

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Mar 2018, accepted on 30 Jun 2018 and first published on 02 Jul 2018


Article type: Paper
DOI: 10.1039/C8FO00423D
Citation: Food Funct., 2018, Accepted Manuscript
  •   Request permissions

    Borago officinalis seed oil (BSO), a natural source of omega-6 fatty acids, attenuates fat accumulation by activating peroxisomal beta-oxidation both in C. elegans and in diet-induced obese rats

    D. Navarro, P. Aranaz, L. Eder-Azanza, M. Zabala, A. Romo Hualde, C. Hurtado, D. Calavia, M. López-Yoldi, J. A. Martinez, C. J. Gonzalez-Navarro and J. L. Vizmanos, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00423D

Search articles by author

Spotlight

Advertisements