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Designing dual-functionalized carbon nanotubes with high blood–brain-barrier permeability for precise orthotopic glioma therapy

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Abstract

Herein we designed and synthesized a cell penetrating peptide- and cancer-targeted molecule-functionalized multi-walled carbon nanotube for precise orthotopic glioma therapy. In addition to reduced toxicity, this nanosystem exhibited enhanced cancer recognition, blood–brain barrier (BBB) penetration, and anticancer activity through increased ROS production.

Graphical abstract: Designing dual-functionalized carbon nanotubes with high blood–brain-barrier permeability for precise orthotopic glioma therapy

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Publication details

The article was received on 01 Oct 2018, accepted on 13 Nov 2018 and first published on 20 Nov 2018


Article type: Communication
DOI: 10.1039/C8DT03948H
Citation: Dalton Trans., 2019, Advance Article
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    Designing dual-functionalized carbon nanotubes with high blood–brain-barrier permeability for precise orthotopic glioma therapy

    Y. You, N. Wang, L. He, C. Shi, D. Zhang, Y. Liu, L. Luo and T. Chen, Dalton Trans., 2019, Advance Article , DOI: 10.1039/C8DT03948H

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