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A Calix[4]arene-Modified (Pc)Eu(Pc)Eu[T(C4A)PP]-based Sensor for Highly Sensitive and Specific Host-Guest Electrochemical Recognition

Abstract

A calix[4]arene (C4A)-functionalized (phthalocyaninato)(porphyrinato) europium(III) triple-decker compound (Pc)Eu(Pc)Eu[T(C4A)PP] (1) is firstly designed, synthesized and prepared into well-organized films using a simple solution-processing quasi-Langmuir-Shäfer (QLS) method. The QLS film of 1 on ITO (film 1/ITO) electrode, serving as a host-guest electrochemical recognition layer, is able to establish specific responses/interactions toward organic molecules with biological and drug interest including dopamine (DA), uric acid (UA), tyrosine (Tyr), tryptophan (Trp) and acetaminophen (APAP), depending mainly on matching degree of molecular dimensions between the analytes and the C4A cavity in addition to their chemical nature. More significantly, the film 1/ITO electrode shows a wide linear range of electrochemical detection (from 0.1 to 100 μM) to DA and APAP, with a high sensitivity of 53.0 and 94.3 μA mM-1 and a very low detection limit of 25 and 11 nM for DA and APAP, respectively, representing the best result among the nonenzymatic organic semiconductor-based biosensors. In particular, the film 1/ITO electrode exhibits excellent stability, reproducibility, highly selectivity, and the anti-interference nature for the detection of both DA and APAP, indicating the great potential of calix[n]arene macrocycle-modified tetrapyrrole rare earth sandwich compounds in the field of ultrasensitive and specific nonenzymatic sensors.

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Supplementary files

Publication details

The article was received on 31 Aug 2018, accepted on 29 Nov 2018 and first published on 30 Nov 2018


Article type: Paper
DOI: 10.1039/C8DT03530J
Citation: Dalton Trans., 2018, Accepted Manuscript
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    A Calix[4]arene-Modified (Pc)Eu(Pc)Eu[T(C4A)PP]-based Sensor for Highly Sensitive and Specific Host-Guest Electrochemical Recognition

    J. Dong, Z. Yu, X. Kong, S. Zhao, X. Li, Y. Chen, Y. Chen and J. Jiang, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C8DT03530J

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