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Diflunisal-adjoined cobalt(III)-polypyridyl complexes as anti-cancer stem cell agents

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Abstract

We report a novel series of cobalt(III)-polypridyl complexes, 4–6, that can selectively release diflunisal, a nonsteroidal anti-inflammatory drug, under reducing conditions. Remarkably, the 1,10-phenanthroline-bearing complex 5 displays selective potency towards hard-to-kill cancer stem cells (CSCs) (IC50 = 2.1 ± 0.1 μM) over bulk cancer (IC50 = 3.9 ± 0.2 μM) and normal cells (IC50 = 21.2 ± 1.3 μM). This complex induces CSC apoptosis by DNA damage and cyclooxygenase-2 inhibition.

Graphical abstract: Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents

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Publication details

The article was received on 24 Aug 2018, accepted on 10 Sep 2018 and first published on 10 Sep 2018


Article type: Communication
DOI: 10.1039/C8DT03448F
Citation: Dalton Trans., 2018, Advance Article
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    Diflunisal-adjoined cobalt(III)-polypyridyl complexes as anti-cancer stem cell agents

    D. O. Abe, A. Eskandari and K. Suntharalingam, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C8DT03448F

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