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Future potential of osmium complexes as anticancer drug candidates, photosensitizers and organelle-targeted probes

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Abstract

Recent work has shown that the chemical reactivity of osmium complexes can be finely tuned by the choice of osmium oxidation state, the ligands (including C- and N-bound), and the coordination geometry and stereochemistry, so opening up a wide range of new potential biological and medical applications. Osmium cancer therapeutics can have diverse modes of action and targets, including DNA interactions, redox modulation and protein inhibition. Polypyridyl Os(II) compounds have potential advantages for luminescent cell imaging and photodynamic therapy due to their favourable photophysical and photochemical properties, such as long-wavelength metal–ligand charge transfer (MLCT) absorptions, high photostability and useful near-infrared (NIR) emission. Here we summarize recent progress in the design and application of innovative organo-osmium compounds as anticancer agents with novel mechanisms and as organelle-targeted imaging probes.

Graphical abstract: Future potential of osmium complexes as anticancer drug candidates, photosensitizers and organelle-targeted probes

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Publication details

The article was received on 22 Aug 2018, accepted on 25 Sep 2018 and first published on 25 Sep 2018


Article type: Perspective
DOI: 10.1039/C8DT03432J
Citation: Dalton Trans., 2018, Advance Article
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    Future potential of osmium complexes as anticancer drug candidates, photosensitizers and organelle-targeted probes

    P. Zhang and H. Huang, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C8DT03432J

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